Startup USA Guide
Part A · Startup-specific scheme

NSF Regional Innovation Engines (NSF Engines)

National Science Foundation

Grant Prototype / PoCSeed / Early-StageGrowth / Scaling

NSF Engines funds regional coalitions of industry, academia, government, nonprofits, and community organizations to build innovation ecosystems around a specific technology or industry focus, aiming to make the region a globally competitive hub within about a decade.

Type of support
Grant
Best suited for
Early-Stage / Growth (regional ecosystem)
Headline amount
Up to $160M per Engine (over 10 years)
How much
~$15M initial award; up to $160M over 10 years

Objectives

Close the gap between federally funded research and regional economic growth by funding multi-year, multi-institution partnerships rather than individual companies — the same instinct as the earlier Build to Scale program, at a much larger scale and time horizon.

Who can apply?

  • Applicants are multi-institutional regional teams (a lead institution plus partner universities, companies, nonprofits, and local government), not individual startups applying directly.
  • A founder benefits by joining, partnering with, or being served by an NSF Engine operating in their region and technology area.
  • NSF Engines Development Awards (Type-1) are a lower-barrier first step for teams not yet ready for a full Engine award.

What do you get?

  • Type-1 Development Awards: up to $1M over up to 2 years, to help a region form a team and plan.
  • Full NSF Engines: start at roughly $15M over the first 2 years, scaling to up to $160M over 10 years for teams that hit milestones.
  • The first 9 inaugural Engines drew more than $2B in matching commitments from industry, philanthropy, and state/local government.

How to apply

Individual founders don't apply directly — check NSF's Regional Innovation Engines page for an active Engine in your region and technology area, or join a regional coalition applying for a new one.

Go to official portal